Predictors for Post-Stroke Depression - Three-Year Longitudinal Study
Refereed conference paper presented and published in conference proceedings

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AbstractBackground and Rationale: Post-stroke depression (PSD) occurs in one third of stroke survivors, leading to greater disability as well as increased mortality. Few prospective studies have explored risk factors to develop PSD. This study aims to investigate the predictors for PSD at early (3-month) and late stages (3-
year) after stroke.

Methods: We recruited 1023 patients with acute ischemic stroke or transient ischemic attack. Demographic factors, vascular risk factors, and neuroimaging markers of small vessel diseases (SVD) were collected at baseline. Statin use was recorded both at baseline and 3-year follow-up. Geriatric depressive score (GDS) 15-items (≥6) was used to ascertain the presence of depression both at 3-month and 3-year after stroke/TIA. Logistic regression was used to explore risk factors for presence of depression at 3-month and delayed-onset depression at 3-year, respectively.

Results: A total of 394 patients experienced depression 3 month after stroke/TIA, leaving 629 depression-free patients. Among these 629 patients, 350 received re-assessment of GDS at 3-year, and 49 (14%) developed depression. At 3-month, severe neurological impairment (OR = 1.09, 95% CI: 1.04–1.14, p < 0.001), cognitive impairment (OR = 0.92, 95% CI: 0.89–0.96, p < 0.001), younger ages (OR = 0.979, 95% CI: 0.961–0.997, p =
0.024) were associated with a higher risk of depression, while statin use (OR = 0.69, 95% CI: 0.49–0.96, p = 0.028) was associated with a decreased risk. At 3-year, presence of lacunes at baseline (OR = 2.2, 95% CI: 1.1–4.3, p = 0.022) and cognitive impairment (OR = 0.88, 95% CI: 0.81–0.96, p = 0.003) were significant risk factors to develop delayed-onset depression, while long-term use of statin (OR = 0.4, 95% CI: 0.2–0.9, P = 0.021) reduced the risk of delayed-onset depression, independent of confounding factors.

Conclusion: Small vessel diseases contributed to the development of delayed-onset depression, whereas use of statin prevented depression both shortly after stroke and at a long-term phase. Mechanisms behind this need further investigations.
All Author(s) ListWang ZL, Lam B, Wong A, Xiong YY, Mok V
Name of ConferenceAsia Pacific Stroke Conference (APSC 2017)
Start Date of Conference26/10/2017
End Date of Conference28/10/2017
Place of ConferenceNanjing
Country/Region of ConferenceChina
Proceedings TitleCerebrovascular Diseases
Series TitleOral Presentations
Volume Number44
Issue NumberSupp 1
Pages47 - 47
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesClinical Neurology;Peripheral Vascular Disease;Neurosciences & Neurology;Cardiovascular System & Cardiology

Last updated on 2022-13-01 at 00:52