Development and Validation of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) Alternate Versions for Screening of Mild Cognitive Impairment
Refereed conference paper presented and published in conference proceedings

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AbstractBackground: The Montreal Cognitive Assessment (MoCA) is a valid and widely used cognitive test in clinical and research settings. However, repeated testing in same individuals results in practice effect which may mask true cognitive changes when evaluating treatment efficacy. The objective of this study is to develop two alternate versions of the Hong Kong version of MoCA (HK-MoCA), together with two alternate versions of the 5-minute protocol and to investigate the validity and reliability of the alternate versions in elderly persons with normal cognition and mild cognitive impairment (MCI) patients. The availability of alternate versions of the HK-MoCA will significantly improve the accuracy in measuring cognitive changes in clinical and research settings.

Methods: Thirty normal controls and 30 patients with MCI were tested with each alternate version (namely V1-HK-MoCA and V2-HK-MoCA) and the original version one month apart of each other. Twenty subjects were further administered the same alternate version one month later to assess test-retest reliability. Correlational and Bland-Altman analyses for the original and alternate versions of HK-MoCA were performed. Criterion validity was assessed by ability to differentiate MCI from controls using receiver operation curve (ROC) analysis. One-month test-retest reliability was indexed by the intra-class correlation coefficient.

Results: The original HK-MoCA and the two alternate versions were highly correlated (V1-HK-MoCA, Pearson r=.87, p<.001; V2-MoCA, Pearson r=.79, p<.001). The alternate versions both showed excellent test-retest reliability (V1-MoCA, Intra-class r=.92, p<.001; V2-MoCA, Intra-class r=.82, p<.001), together with good internal consistency (V1-MoCA: α=.79; V2-MoCA: α=.75). The alternate versions also showed excellent to good ability to detect MCI from normal (ROC area under curve: V1-MoCA=0.92; V2-MoCA=0.72). Bland-Altman analysis of the alternate versions showed a high level of agreement with the original HK-MoCA with no proportional bias.

Conclusions: The alternate versions of HK-MoCA are valid for screening of MCI with excellent test-retest reliability.
All Author(s) ListYiu YPS, Leung KT, Mok VCT, Soo OYY, Wong A
Name of ConferenceAlzheimer’s Association International Conference (AAIC) 2017
Start Date of Conference16/07/2017
End Date of Conference20/07/2017
Place of ConferenceLondon
Country/Region of ConferenceGreat Britain
Proceedings TitleAlzheimer's & Dementia: The Journal of the Alzheimer's Association - 2017 Abstract Supplement
Series TitlePoster Presentations: Sunday, July 16, 2017
Number in SeriesP1-500
Year2017
Month7
Volume Number13
Issue Number7 Supplement
PublisherElsevier
Pages483 - 483
LanguagesEnglish-United Kingdom

Last updated on 2021-18-01 at 01:19