Long non-coding RNAs in the regulation of skeletal myogenesis and muscle diseases
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AbstractSkeletal muscle myogenesis during development and the injury induced regeneration contribute to the formation and maintenance of muscle tissue. Emerging studies have demonstrated that long non-coding RNAs (IncRNAs) participate in the regulation of gene expression during skeletal myogenesis and their aberrant expression is associated with several muscular diseases. In this review, we summarize recent studies of IncRNAs in the regulation of myogenesis and muscle diseases with mechanistic characterization. These findings have greatly enhanced our understanding of gene regulatory mechanisms governing muscle formation and regeneration, which will eventually lead to novel therapeutics against various muscle diseases.
All Author(s) ListLi YY, Chen XN, Sun H, Wang HT
Journal nameCancer Letters
Volume Number417
Pages57 - 64
LanguagesEnglish-United States

Last updated on 2021-14-10 at 23:42