A prospective study to monitor for tuberculosis during anti-tumour necrosis factor therapy in patients with inflammatory bowel disease and immune mediated inflammatory diseases
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AbstractBACKGROUND:
Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking.

METHODS:
Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years. Incidence and risk factors of latent tuberculosis tests conversion [Interferon gamma release assays (IGRA), tuberculin skin test (TST) and chest radiography (CXR)] with clinical outcomes were studied.

RESULTS:
A total of 108 patients (83 IBD; 25 rheumatological disorders) were included. At baseline, 18/108 (16.7%) patients (5 IBD; 13 rheumatological disorders) were tested positive for LTBI. 14/18 (77.8%) patients received isoniazid monotherapy for 9 months. 17/90 (18.9%) patients had LTBI test conversion while on biologic therapies and 14/17 (82.4%) received isoniazid monotherapy for 9 months. Age, sex, smoking status, alcohol use, travel history, disease type or immunosuppressive therapy were not associated with LTBI test conversion. In subjects with IGRA conversion, serial IGRA levels normalised after completion of isoniazid except one patient whose IGRA remained persistently elevated despite isoniazid and subsequently developed active TB.

CONCLUSION:
Conversion of LTBI is common and occurred early during biologic therapy in an area with intermediate TB burden. Subjects with latent TB tests conversion and persistently high IGRA levels may have an increased risk of TB reactivation or development of active TB and they require close observation or intensive workup for active TB.
Acceptance Date09/05/2018
All Author(s) ListChoon Kin Lee, Sunny H v Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Journal nameJournal of Crohn's and Colitis
Year2018
Month8
Volume Number12
Issue Number8
PublisherOxford University Press
Pages954 - 962
ISSN1873-9946
eISSN1876-4479
LanguagesEnglish-United Kingdom
KeywordsBiologic therapy, tuberculosis, inflammatory bowel disease

Last updated on 2020-24-05 at 01:39