Clinical pattern and prevalence of upper gastrointestinal toxicity in patients abusing ketamine
Publication in refereed journal

替代計量分析
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其它資訊
摘要OBJECTIVE
Evaluations of upper gastrointestinal toxicity from ketamine abuse are uncommon. This study investigated the clinical pattern of upper gastrointestinal symptoms in patients inhaling ketamine.
METHODS
In a cross-sectional study of 611 consecutive patients who were seeking treatment for ketamine uropathy in a tertiary hospital setting between August 2008 and June 2016, their clinical pattern of upper gastrointestinal symptoms was evaluated and compared with a control population of 804 non-users.
RESULTS
A total of 168 (27.5%) patients abusing ketamine (mean age 26.3 years, 58.9% female) reported the presence of upper gastrointestinal symptoms. These symptoms were significantly more prevalent in patients inhaling ketamine than in those who were not (27.5% vs 5.2%, P < 0.001). Their mean duration of ketamine abuse before symptom presentation was 5.0 3.1 years. The presenting symptoms included epigastric pain (n = 155, 25.4%), recurrent vomiting (n = 48, 7.9%), anemia (n = 36, 5.9%) and gastrointestinal bleeding (n = 20, 3.3%). Uropathy symptoms were preceded by upper gastrointestinal symptoms for 4.4 +/- 3.0 years in 141 (83.9%) patients. Logistic regression showed that elder age (odds ratio [OR] 1.06, P = 0.04), active abuser status (OR 1.60, P = 0.04) and longer duration of ketamine abuse (OR 1.00, P = 0.04) were independent factors associated with upper gastrointestinal toxicity.
CONCLUSIONS
Although epigastric symptoms are unusual in the young population, upper gastrointestinal toxicity was highly prevalent in those inhaling ketamine. Enquiries about ketamine abuse are recommended when assessing young patients with epigastric symptoms.
著者Liu SYW, Ng SKK, Tam YH, Yee SCH, Lai FPT, Hong CYL, Chiu PWY, Ng EKW, Ng CF
期刊名稱Journal of Digestive Diseases
出版年份2017
月份9
卷號18
期次9
出版社Wiley
頁次504 - 510
國際標準期刊號1751-2972
電子國際標準期刊號1751-2980
語言英式英語
關鍵詞gastrointestinal diseases, ketamine, stomach, substance-related disorders, upper gastrointestinal tract
Web of Science 學科類別Gastroenterology & Hepatology;Gastroenterology & Hepatology

上次更新時間 2020-06-08 於 02:59