MicroRNA-125b Interacts with Foxp3 to Induce Autophagy in Thyroid Cancer
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AbstractThyroid cancer is rapidly increasing in incidence worldwide. Although most thyroid cancer can be cured with surgery, radioactive iodine, and/or chemotherapy, thyroid cancers still recur and may become chemoresistant. Autophagy is a complex self-degradative process that plays a dual role in cancer development and progression. In this study, we found that miR-125b was downregulated in tissue samples of thyroid cancer as well as in thyroid cancer cell lines, and the expression of Foxp3 was upregulated. Further, we demonstrated that miR-125b could directly act on Foxp3 by binding to its 3' UTR and inhibit the expression of Foxp3. A negative relationship between miR-125b and Foxp3 was thus revealed. Overexpression of miR-125b markedly sensitized thyroid cancer cells to cisplatin treatment by inducing autophagy through an Atg7 pathway in vitro and in vivo. Taken together, our findings demonstrate a novel mechanism by which miR-125b has the potential to negatively regulate Foxp3 to promote autophagy and enhance the efficacy of cisplatin in thyroid cancer. miR-125 may be of therapeutic significance in thyroid cancer.
All Author(s) ListWang SS, Wu JK, Ren JW, Vlantis AC, Li MY, Liu SYW, Ng EKW, Chan ABW, Luo DC, Liu ZM, Guo W, Xue LB, Ng SK, van Hasselt CA, Tong MCF, Chen GG
Journal nameMolecular Therapy
LanguagesEnglish-United Kingdom

Last updated on 2020-06-07 at 01:25