Re-analysis of Whole-exome Sequencing Data of EBV(+) NPC and HPV(+) HNSCC Reveals Genomic Commonalities in Major Patient Subsets
Refereed conference paper presented and published in conference proceedings


摘要Epstein-Barr virus positive nasopharyngeal carcinoma [EBV(+) NPC], and human papillomavirus-positive head and neck squamous cell carcinoma [HPV(+) HNSCC] are two distinct types of aggressive head and neck cancers with early age onsets. Whole-exome sequencing data for these head and neck cancers have recently been made publicly available. Based on six major pathways that are recognized to be important in these cancers, we systematically compared their mutational landscapes (by re-analyzing our recently published EBV(+) NPC and HPV(+)HNSCC TCGA WES data). Our findings reveal that both EBV(+) NPC and HPC(+) HNSCC are frequently mutated with genetic events that are associated with: 1) inflammation via NF-kB activation (>30% cases), 2) survival via PI3K aberrations (20-50% cases), as well as, 3) immune evasion via MHC Class I gene aberrations (>20% cases). Though previous publications on these two cancers establish that EBV(+) NPC is an NF-kB-driven cancer, and HPV(+) HNSCC is a PI3K-driven cancer, our findings indicate major commonalities in genetic events for these two virally-associated head and neck cancers of the East and West. Lastly, we identified that ~38% of EBV(+) NPC and 58% of HPV(+) HNSCC carry potentially druggable events.
著者Hoi-Lam NGAN, Lan WANG, Kwok-Wai LO, Vivian Wai Yan LUI
會議名稱Gordon Research Conferences on Nasopharyngeal Carcinoma
會議地點Hong Kong

上次更新時間 2018-22-11 於 15:40