Bone health in premenopausal Chinese patients after adjuvant chemotherapy for early breast cancer
Refereed conference paper presented and published in conference proceedings


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AbstractBackground: Adjuvant chemotherapy improves survival of patients (pts)with early breast cancer. However, it may be associated with long term toxicities. Among premenopausal Chinese women with early breast cancer,there is limited data on profiles of bone health after having received adjuvant chemotherapy.

Patients and Methods: Premenopausal Chinese pts were recruited into this cross-sectional study. Eligibility criteria include breast cancer pts of stage I-III, younger than 45 years at diagnosis, having received adjuvant chemotherapy, within 3–10 years after the diagnosis of breast cancer. Details of their breast cancer at initial diagnosis along with the adjuvant treatment they received were being collected. At study entry, pts provided their demographic information. All pts had the menopausal status determine, and all underwent assessment for bone health based on DEXA scan.

Results: A total of 280 eligible pts were recruited; 271 had DEXA assessment. The median time from breast cancer diagnosis to study entry was 5.0 years. Of the 271 pts, the age at breast cancer diagnosis were 50.109 (40.2%) pts remained premenopausal, 28 (10.3%) were peri-menopausal and 134 (49.5%) were postmenopausal. The median Zscore for hip was 0.00 (interquartile range [IQR]: −0.7 to +0.8); that for spine was −0.40 (IQR: −1.2 to +0.3). 109 pts (40.2%) had Z score.

Conclusion: At a median of 5 years after breast cancer diagnosis and adjuvant chemotherapy, over half of the studied pts had osteopenia/ osteoporosis in hip or spine, and 40% were detected to have low Z score for either hip or spine. Further research is needed to assess possible associated factors for changes in bone health among young pts after cytotoxic chemotherapy.
Acceptance Date21/03/2018
All Author(s) ListW Yeo, GS Liem, J Suen, E Pang, R Ng, CHW Yip, FKF Mo
Name of Conference11th European Breast Cancer Conference (EBCC-11)
Start Date of Conference21/03/2018
End Date of Conference23/03/2018
Place of ConferenceBarcelona
Country/Region of ConferenceSpain
Proceedings TitleEuropean Journal of Cancer
Year2018
Month4
Volume Number92
Issue NumberSuppl 3
PublisherElsevier
PagesS51 - S51
ISSN0959-8049
eISSN1879-0852
LanguagesEnglish-United Kingdom
KeywordsBone health, chemotherapy

Last updated on 2020-02-08 at 02:53