A 5-Year Longitudinal Study of Cognitive Decline After Stroke/Transient Ischemic Attack (CU-STRIDE)
Invited conference paper presented and published in conference proceedings


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AbstractBackground and Rationale: Dementia after stroke/transient ischemic attack (TIA) could occur immediately or with a delayedonset. Patients who were cognitively intact initially have a high risk of developing dementia at a later stage. We aimed to investigate the risk factors and underlying etiology of delayed-onset poststroke dementia (PSD).

Methods: Stroke/TIA patients (n = 1,007) were recruited into the Chinese University of Hong Kong STroke Registry Investigating cognitive DEcline (CU-STRIDE) study with a follow-up annually for 5 years. We investigated the incidence of dementia per year, with dementia defined as having a Clinical Dementia Rating scale of ≥1. We studied the associations between baseline vascular, genetic, imaging risk factors, and recurrent stroke with delayedonset
PSD using a logistic regression model.

Results: Patients who developed dementia 3–6 months after stroke (n = 88) were excluded, as we aim to focus on those with delayed-onset PSD. After the 5-year study period, 235/919 subjects remained. The cumulative incident dementia cases were 132/919. The new incident dementia cases were as follow: 2.7% (Year 1), 1.7% (Year 2), 1.3% (Year 3), 1.0% (Year 4), and 1.3% (Year 5). Random forest was used in variable selection. Diabetes mellitus (OR = 2.2, 95% CI = 1.2 to 4.0, p = 0.015) and multiple lacunes (≥3) (OR = 3.2, 95% CI = 1.7 to 5.9, p < 0.001) were significant predictors of delayed-onset PSD, after adjustment for age and education. The presence of ApoE ε4 and recurrent stroke were not significant predictors of delayed-onset PSD.

Conclusion: Diabetes mellitus and multiple lacunes were significant predictors of delayed-onset PSD.
All Author(s) ListLam B, Wong A, Wang ZL, Liu WY, Au L, Chan A, Lau A, Shi L, Fan F, Ma SH, Ip V, Soo Y, Leung T, Leng XY, Chen XY, Chu W, Mok V
Name of ConferenceAsia Pacific Stroke Conference (APSC 2017)
Start Date of Conference26/10/2017
End Date of Conference28/10/2017
Place of ConferenceNanjing
Country/Region of ConferenceChina
Proceedings TitleCerebrovascular Diseases
Series TitleOral Presentations
Title of PublicationCEREBROVASCULAR DISEASES
Year2017
Month10
Volume Number44
Issue NumberSupp 1
PublisherKARGER
Pages4 - 4
ISSN1015-9770
eISSN1421-9786
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesClinical Neurology;Peripheral Vascular Disease;Neurosciences & Neurology;Cardiovascular System & Cardiology

Last updated on 2020-02-06 at 01:06