Magnetic resonance imaging-based morphological changes of paraspinal muscles in girls with adolescent idiopathic scoliosis
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction
Several studies have reported abnormalities in biochemical, electromyographic activity (EMG) and histological changes of paraspinal muscles in AIS patients. However, these studies only had qualitative data without the comparison with healthy controls. Change of muscle mass and mean density at the lumbar region have also been described for scoliotic spines. All these findings suggested that imbalance of paraspinal muscles in AIS patients could be a contributing factor to the development of more severe scoliotic curve.
Objectives
To investigate and compare any morphological differences in paraspinal muscles between AIS patients with different curve severities and healthy controls.
Methods
T2-weighted MR images with multi-planar reconstruction were acquired in 64 Chinese female adolescents including AIS girls with primary right-side thoracic curves (17 mild to moderate, 24 severe curves), and 23 age-matched controls. In AIS subjects, measurements of the paraspinal muscles were taken on both concavity and convexity
of the scoliotic curve starting from two vertebral levels above and two vertebral levels below the scoliotic apex. Morphological assessments of the multifidus (MF) and erector spinae (ES) muscles on both sides were made including signal intensity, area and fat deposition using ROI based approach, manual tracing and thresholding technique respectively. Same parameters were measured in healthy controls at matched vertebral levels. Ratios were taken as concave/ convex (for AIS) or left / right (for controls). One-way ANOVA test with Post Hoc test of Bonferroni correction was used for comparison. Cobb angle was correlated with anthropometric parameters using pearson correlation test.
Results & discussion
In AIS, signal intensity was significantly higher at the multifidus of paraspinal muscles on the concave side, when compared with the controls. Higher ratios of signal intensity and fatty components were noted within the concave muscle when compared with the convex side (P-value <0.01). A significant correlation was found between Cobb angle and signal intensity within the concave muscle at the apical level.
Conclusion & significance
Increased signal intensity and fatty components are asymmetrically present in the paraspinal muscles at the apex level in AIS. Our results showed higher intensity in paraspinal muscle at the concavity of the curve in AIS when compared with controls. There was also significant linear correlation between abnormal muscle signal and scoliotic curve. Above features are suggestive of altered muscle composition in the concave paraspinal muscle, possibly due to distortion and prolonged stretching of the paraspinal muscle caused by the spinal deformity.
All Author(s) ListKwong Hang Yeung, Gene Chi Wai Man, Shi Lin, Steve Cheuk Ngai Hui, Tsz Ping Lam, Bobby Kin Wah Ng, Jack Chun Yiu Cheng, Winnie Chiu Wing Chu
Name of ConferenceThe 12th Meeting of International Research Society on Spinal Deformities (IRSSD)
Start Date of Conference14/06/2018
End Date of Conference16/06/2018
Place of ConferenceUtrecht
Country/Region of ConferenceNetherlands
Proceedings TitleScoliosis and Spinal Disorders
Year2018
Month6
Volume Number13
Issue NumberSupp 1
Pages26 - 26
ISSN2397-1789
LanguagesEnglish-United Kingdom

Last updated on 2018-20-11 at 16:58