Dietary Soy intake and breast cancer survival in Chinese Women
Invited conference paper presented and published in conference proceedings

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AbstractBreast cancer (BC) is presently among the most frequently diagnosed cancer in Asian women. With earlier detection and advances in cancer treatment, BC survival has improved substantially. Soy foods have generated considerable interest among BC survivors for promoting health; but have also raised much concern because of conflicting reports of soy effects on BC prognosis.

A cohort study comprising 1,497 BC survivors recruited since 2010 was conducted to evaluate the association of soy food Intake with BC survival. All were diagnosed with primary BC within 12 months of study entry, and had no prior history of breast or other cancers. Face-to-face interviews based on structured questionnaire were conducted at entry to collect information on socio-demographic, medical, reproductive and lifestyle factors. Soy food intake and overall diet during the year prior to diagnosis were collected based on validated food frequency questionnaire. The interviews were repeated at 18-month and 36-month follow up. The 60-month follow up interviews are still on-going. Information on mortality were obtained from active follow-up and computerized clinical management System.

The mean age of the cohort was 51.8+9.07 years, and 52.2 % were premenopausal. 83.3 % of the BC were of the invasive ductal carcinoma type, and about 80% belonged to cancer stage 0-1. The mean intake of soy isoflavone was 9.73 (+11.35 ) mg/day. 75 deaths(4.3% premenopausal and 6.1% postmenopausal) occurred during follow up till March 2017, with mean follow up time follow up time 56.8+9.9 months. After adjustment for the potential confounders (age, education, body mass index, types of therapies, ER/PR status, cancer stage, menopausal status, and dietary energy intake), all-cause mortality was observed to be lower among women of the second and third soy isoflavone intake quartiles (adjusted odds ratio 0.70, 95% C.I. 0.34-1.42; 0.55, 95% C.I. 0.26-1.18), but the association was statistically non-significant. Stratified analysis showed the mortality risk was slightly lower in premenopausal survivors. Our prospective study showed that pre-diagnosis soy intake did not increase the risk of all-cause mortality in BC survivors. This study is still ongoing and longer follow up will provide further evidence on the effect of post-diagnosis soy Intake on BC survival.
All Author(s) ListHo S, Yeo W, Lee R, Lee CKI, Sham A, Lei YY, Cheung KL, He YQ
Name of Conference21st World Congress of Clinical Nutrition
Start Date of Conference06/10/2017
End Date of Conference08/10/2017
Place of ConferenceBudapest
Country/Region of ConferenceHungary
Place of PublicationHungary
Pages74 - 74
LanguagesEnglish-United Kingdom
KeywordsBreast Cancer, Chinese women

Last updated on 2018-01-11 at 12:14