A randomized controlled trial (RCT) comparing the efficacy and safety of pattern laser trabeculoplasty (PLT) and selective laser trabeculoplasty (SLT)
Invited conference paper presented and published in conference proceedings


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摘要Purpose : To compare the intraocular pressure (IOP) lowering effect and adverse effects of PLT and SLT in the treatment of primary open-angle glaucoma (POAG) or ocular hypertension (OHT).

Methods : 126 eyes of 126 patients with POAG/OHT were recruited. 62 eyes received SLT and 64 eyes received PLT for 360 degrees of the anterior chamber angle after medication washout. They were followed up at 1 day, 1 week, 1, 3, 6, 9 and 12 months. Mean diurnal Goldmann applanation tonometry measurements at 9-10am, 12-1pm, and 5-6pm were measured at baseline, month 6(M6) and month 12(M12). Humphrey 24-2 visual field, optical coherence tomography of retinal nerve fiber layer (RNFL) imaging were performed. Topical IOP-lowering medication was given if IOP was >=25mmHg and/or functional/structural progression was detected. Complete treatment success was defined as 15% IOP reduction without medication.

Results : 62 and 61 eyes reached M6 follow-up, and 47 and 44 eyes reached M12 follow-up in the PLT- and SLT-treated groups, respectively. Mean baseline IOP was 21.0 +/- 4.1mmHg for PLT and 21.2 +/- 4.7mmHg for SLT (p=0.900). In both PLT and SLT group, there were significant reductions in the mean IOP at both M6 by 1.8±3.8 and 2.7±3.5mmHg, respectively(p<0.001), and M12 by 2.9±3.8 and 3.7±4.3 mmHg, respectively (p<0.001). There were no significant differences in mean IOP between the SLT- and PLT-treated groups at M6 and M12 (p>0.05). At M12, the IOP at 9-10am, 12-1pm and 5-6pm was 19.3, 18.5, and 17.6 mmHg, respectively, for PLT; and 18.8, 18.5, and 17.4mmHg, respectively, for SLT. No significant differences in IOP were detected at the individual time points between both groups (p>0.05). Complete success in the PLT- and SLT-treated group were 25.8% and 31.1%, respectively, at M6, and 25.5% and 31.8%, respectively, at M12. 28.6% and 27.8% of eyes required additional medications at M12 in the PLT- and SLT-treated groups, respectively. There was no significant difference in the proportions of patients requiring medications at M6 and M12(p>0.05). There were no major adverse events in both groups.

Conclusions : The IOP-lowering efficacy and safety were similar between PLT and SLT.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
著者Oi Man Mandy Wong, Isabel Sum Wai Lai, Chan PP, Ching Yan Noel Chan, Leung CK
會議名稱Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting 2018
會議開始日29.04.2018
會議完結日03.05.2018
會議地點Honolulu, Hawaii
會議國家/地區美國
會議論文集題名Investigative Ophthalmology & Visual Science
出版年份2018
月份7
卷號59
期次9
國際標準期刊號0146-0404
電子國際標準期刊號1552-5783
語言英式英語

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