Candida albicans orf19.3727 encodes phytase activity and is essential for human tissue damage
Publication in refereed journal

香港中文大學研究人員
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其它資訊
摘要Candida albicans is a clinically important human fungal pathogen. We previously identified the presence of cell-associated phytase activity in C. albicans. Here, we reveal for the first time, that orf19.3727 contributes to phytase activity in C. albicans and ultimately to its virulence potency. Compared with its wild type counterpart, disruption of C. albicans orf19.3727 led to decreased phytase activity, reduced ability to form hyphae, attenuated in vitro adhesion, and reduced ability to penetrate human epithelium, which are the major virulence attributes of this yeast. Thus, orf19.3727 of C. albicans plays a key role in fungal pathogenesis. Further, our data uncover a putative novel strategy for anti-Candidal drug design through inhibition of phytase activity of this common pathogen.
出版社接受日期21.11.2017
著者Paul Wai-Kei Tsang, Wing-Ping Fong, Lakshman Perera Samaranayake
期刊名稱PLoS ONE
出版年份2017
月份12
日期7
卷號12
期次12
文章號碼e0189219
國際標準期刊號1932-6203
語言美式英語
關鍵詞Candida albicans, phytase, tissue damage

上次更新時間 2020-19-10 於 03:29