Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Publication in refereed journal


摘要Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. Recently, a growing number of studies tend to put Hippo on inflammatory and immunological focus: its antimicrobial role in flies, its pro- or anti-inflammation in mammals, as well as its relevance to cancerous immunity. From inflammation to tumor immunogenicity, Hippo has been gradually justified to play a crucial role. This review summarized the latest findings regarding the involvement of Hippo pathway in immunity, and a more comprehensive understanding of Hippo pathway will shed light on clinical translational potential even precision medicine.
著者Yuhang ZHOU, Tingting HUANG, Jinglin ZHANG, Alfred S.L. CHENG, Jun YU, Wei KANG, Ka Fai TO
期刊名稱Cancer Letters
頁次73 - 79
關鍵詞Hippo pathway, YAP, Immune microenvironment

上次更新時間 2020-29-07 於 01:38