Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
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AbstractInitially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. Recently, a growing number of studies tend to put Hippo on inflammatory and immunological focus: its antimicrobial role in flies, its pro- or anti-inflammation in mammals, as well as its relevance to cancerous immunity. From inflammation to tumor immunogenicity, Hippo has been gradually justified to play a crucial role. This review summarized the latest findings regarding the involvement of Hippo pathway in immunity, and a more comprehensive understanding of Hippo pathway will shed light on clinical translational potential even precision medicine.
All Author(s) ListYuhang ZHOU, Tingting HUANG, Jinglin ZHANG, Alfred S.L. CHENG, Jun YU, Wei KANG, Ka Fai TO
Journal nameCancer Letters
Year2018
Month7
Day10
Volume Number426
Pages73 - 79
ISSN0304-3835
LanguagesEnglish-United Kingdom
KeywordsHippo pathway, YAP, Immune microenvironment

Last updated on 2020-13-07 at 01:35