Unique correlation pattern between bone qualities and handgrip strength in adolescent idiopathic scoliosis (AIS) girls
Refereed conference paper presented and published in conference proceedings


其它資訊
摘要Introduction
Previous studies reported the association between adolescent idiopathic scoliosis (AIS) and low bone mass and poor bone health. Cross-talk between bone and muscle was recently described receiving wide attention and can potentially shed lights on the nature of poor bone health and its role in the etiopathogenesis of AIS. In spite of this and to the best of our knowledge, studies on both bone and muscle parameters and their correlation in AIS have not been reported in the literature.

Objectives: To investigate the correlation between handgrip strength and bone qualities (volumetric bone mineral density (vBMD), bone geometry, trabecular bone micro-architecture) and bone mechanical properties in girls with AIS versus age- matched normal girls.

Methods
142 AIS girls and 247 non-AIS girls aged 12-14 years old were recruited. Maximum handgrip strength was measured with a standard dynamometer and bone qualities of non-dominant distal radius were measured by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone mechanical properties were assessed by Finite
Element Analysis (FEA). Partial correlation was used to control confounding from age, arm span and weight in data analysis.

Results and discussions
In non-AIS girls and after adjustment for confounders, handgrip strength was positively correlated with bone area (R = 0.17, p = 0.01 in cortical area and R = 0.24, p < 0.001 in trabecular area) and bone mechanical properties (R = 0.25 in stiffness and R = 0.24 in failure load, both p < 0.001), but not correlated with vBMD and trabecular bone micro-architecture. In contrast for AIS girls, handgrip strength was positively correlated with cortical area (R = 0.22, p < 0.01), cortical thickness (R = 0.19, p=0.03), and bone mechanical properties (stiffness, failure load and apparent
modulus, R = 0.22 – 0.33, all p < 0.05) but negatively correlated with structure model index (R = -0.18, p = 0.04), which reflects the trabecular plate-rod ratio.

Conclusions and significance
This study indicated unique correlation patterns between bone qualities and handgrip strength in AIS as distinct from controls. This finding suggests the characteristic bone-muscle cross talk in AIS could play an important role in the etiopathogenesis of AIS. Further longitudinal studies to investigate if handgrip strength can be used as a surrogate for bone parameters and the role of handgrip strength in predicting curve progression in AIS are warranted.

Acknowledgement
This study is supported by RGC of HKSAR (468809 & 468411).
著者Ka-Yee Cheuk, Vivian WY Hung, Fiona WP Yu, Lyn LN Wong, Wayne YW Lee, Jack CY Cheng, Tsz-Ping Lam
會議名稱The 12th Meeting of International Research Society on Spinal Deformities (IRSSD)
會議開始日14.06.2018
會議完結日16.06.2018
會議地點Utrecht
會議國家/地區荷蘭
會議論文集題名Scoliosis and Spinal Disorders
出版年份2018
月份6
卷號13
期次Supp 1
頁次6 - 6
國際標準期刊號2397-1789
語言英式英語

上次更新時間 2018-16-11 於 15:37