The associations between circadian rest-activity rhythm and neuropsychological functions in idiopathic REM sleep behavior disorder: a cross-sectional study
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摘要Background: Accumulating evidence indicates that circadian rhythm, such as rest-activity rhythm and circadian plasma melatonin, is associated with cognitive and neurological functions at different stages of Parkinson’s disease (PD). However, whether these associations exist in idiopathic REM sleep behavior disorder (iRBD) remains unknown.
Objective: To determine whether circadian rest-activity rhythm is related to neuropsychological functions in iRBD patients.
Methods: 102 iRBD patients [age: 68.9 ± 8.5 years; males (%): 71%] were recruited. Wrist-worn actigraphy for seven days was used to measure the circadian rest-activity rhythm parameters, including intradaily variability, interdaily stability, percentage of rhythm, mesor, amplitude and acrophase. RBD questionnaire-Hong Kong (RBDQ-HK) was used to measure the severity of RBD symptoms. Mini-mental state examination (MMSE) was used to evaluate cognitive function. The unified Parkinson's disease rating scale-Part3 (UPDRS-Part3) was employed to measure motor function. All correlations were analyzed by Partial correlation after adjustment for age and sex.
Results: MMSE score was significantly associated with intradaily variability (r = -0.25; P < 0.05) and mesor (r = 0.22; P < 0.05), but not with interdaily stability, percentage of rhythm, amplitude and acrophase (all P > 0.05). UPDRS-Part3 score was negatively correlated with interdaily stability (r = -0.23; P < 0.05), but not other circadian rhythm parameters (all P > 0.05). There were no significant relationships of RBDQ-HK score with any circadian rhythm parameters (all P > 0.05).
Conclusions: Intradaily variability, indicating the fragmentation of rest-activity rhythm, and mesor, indicating circadian rhythm-adjusted mean of activity level, are associated with cognitive function, while interdaily stability, indicating stability of rest-activity rhythm, is more likely to be correlated with motor function in iRBD patients. However, circadian rest-activity rhythm parameters are not correlated with severity of RBD symptoms. Longitudinal studies are needed to delineate these potential causal relationships.
出版社接受日期20.01.2018
著者Hongliang Feng, Siu Ping Lam, Shirley Xin Li, Yaping Liu, Yun Kwok Wing, Jihui Zhang
會議名稱2nd Congress of Asian Society of Sleep Medicine
會議開始日22.03.2018
會議完結日25.03.2018
會議地點Seoul
會議國家/地區韓國
出版年份2018
語言美式英語
關鍵詞Circadian rhythm, Neuropsychological functions, Idiopathic RBD

上次更新時間 2018-05-10 於 17:10