Whole body vibration therapy triggers load-driven bone formation in adolescents with idiopathic scoliosis
Refereed conference paper presented and published in conference proceedings


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AbstractAdolescent idiopathic scoliosis (AIS) is a spinal deformity that can lead to severe morbidity and mainly affects peripubertal girls. Using micro-finite element (micro-FE) models derived from high-resolution quantitative computed tomography (HR-pQCT) images, it has been shown that bone strength is significantly lower in AIS versus healthy
control. Whole body vibration (WBV) therapy is a suggestive solution because pharmacological drugs are not recommended for the affected adolescents. Nevertheless, the effects of WBV therapy on bone mechanical integrity has not been investigated yet and therefore was the purpose of the present study.

HR-pQCT images of the distal tibia section scanned clinically in young AIS females using XtremeCT (Scanco Medical) were used from a previous study to derive micro-FE models. TheWBVgroup (n=30) was standing on a low-magnitude high-frequencyWBV plate (Juvent 1000 DMT, Juvent Medical, 32-37 Hz, 0.085 mm) for 20 min/day, 5 days/ week for 12 months, whereas the AIS control group (n=24) was only observed. Imaging was performed at baseline and 12-month follow-up. Bone strength and local tissue loading were estimated using micro-FE analysis.

No significant differences were found in bone strength changes over 12 months between the AIS control and WBV group. However, the treatment group showed larger increases in bone strength in some patients, indicating that WBV therapy can have an effect. Treated patients showing a considerable increase in bone strength (upper third group, n=10) revealed a significant (p<0.01) decrease of local peak loading (98th percentile) after 12-month WBV (Fig. 1). In contrast, treated patients showing a considerable decrease in bone strength (lower third group, n=10) revealed a significant (p<0.01) increase of local peak loading (98th percentile). Furthermore, serological study showed that adequate vitamin D status could be a prerequisite for this bone formation as baseline levels were on average higher (48.1 versus 40.6 nmol/l, p=0.09) in the upper third group than in the lower third group.

This in-depth imaging analysis supports previous clinical observation of increased femoral bone density in AIS patients receiving WBV and suggests that WBV therapy might trigger load-driven bone formation in patients displaying a considerable increase in bone strength (upper third group). These patients also showed higher serum vitaminD levels, however, a larger cohort study is warranted to validate these findings.
All Author(s) ListP. Christen, G. Marano, Y.-W. W. Lee, T.-P. Lam, R. Müller
Name of Conference2017 Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
Start Date of Conference08/09/2017
End Date of Conference11/09/2017
Place of ConferenceDenver, Colorado
Country/Region of ConferenceUnited States of America
Proceedings TitleJOURNAL OF BONE AND MINERAL RESEARCH
Year2017
Month12
Volume Number32
Issue NumberSuppl 1
Place of PublicationUSA
PagesS187 - S187
ISSN0884-0431
eISSN1523-4681
LanguagesEnglish-United Kingdom

Last updated on 2020-07-08 at 00:57