Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015
Publication in refereed journal

替代計量分析
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其它資訊
摘要Background
Many serologic studies were done during and after the 2009 influenza pandemic, to estimate the cumulative incidence of influenza A(H1N1)pdm09 virus infections, but there are few comparative estimates of the incidence of influenza A(H3N2) virus infections during epidemics.

Methods
We conducted a longitudinal serologic study in Hong Kong. We collected sera annually and tested samples from 2009–13 by HAI against the A/Perth/16/2009(H3N2) virus, and samples from 2013–15 against the A/Victoria/361/2011(H3N2) virus using the hemagglutination inhibition (HAI) assay. We estimated the cumulative incidence of infections based on 4-fold or greater rises in HAI titers in consecutive sera.

Results
There were four major H3N2 epidemics: (1) Aug-Oct 2010; (2) Mar-Jun 2012; (3) Jul-Oct 2013; and (4) Jun-Jul 2014. Between 516 and 619 relevant pairs of sera were available for each epidemic. We estimated that 9%, 19%, 7% and 7% of the population were infected in each epidemic, respectively, with higher incidence in children in epidemics 1 and 4.

Conclusions
We found that re-infections in each of the four H3N2 epidemics that occurred from 2010 through 2014 were rare. The largest H3N2 epidemic occurred with the lowest level of pre-epidemic immunity.
出版社接受日期03.05.2018
著者Wei VWI, Wong JYT, Perera RAPM, Kwok KO, Fang VJ, Barr IG, Peiris JSM, Riley S, Cowling BJ
期刊名稱PLoS ONE
出版年份2018
月份5
日期24
卷號13
期次5
出版社Public Library of Science
文章號碼e0197504
國際標準期刊號1932-6203
語言英式英語

上次更新時間 2021-19-01 於 02:23