Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers
Publication in refereed journal

替代計量分析
.

其它資訊
摘要BACKGROUND:

Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level.

RESULTS:

Based on the combined analysis of 526 metagenomic samples from Chinese, Austrian, American, and German and French cohorts, seven CRC-enriched bacteria (Bacteroides fragilis, Fusobacterium nucleatum, Porphyromonas asaccharolytica, Parvimonas micra, Prevotella intermedia, Alistipes finegoldii, and Thermanaerovibrio acidaminovorans) have been identified across populations. The seven enriched bacterial markers classified cases from controls with an area under the receiver-operating characteristics curve (AUC) of 0.80 across the different populations. Abundance correlation analysis demonstrated that CRC-enriched and CRC-depleted bacteria respectively formed their own mutualistic networks, in which the latter was disjointed in CRC. The CRC-enriched bacteria have been found to be correlated with lipopolysaccharide and energy biosynthetic pathways.

CONCLUSIONS:

Our study identified potential diagnostic bacterial markers that are robust across populations, indicating their potential universal use for non-invasive CRC diagnosis. We also elucidated the ecological networks and functional capacities of CRC-associated microbiota.
出版社接受日期19.03.2018
著者Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K. K. Wu, Liuyang Zhao, Zigui Chen, Francis K. L. Chan, Karsten Kristiansen, Joseph J. Y. Sung, Sunny Hei Wong, Jun Yu
期刊名稱Microbiome
出版年份2018
月份4
日期11
卷號6
期次70
出版社BioMed Central
文章號碼70
國際標準期刊號2049-2618
語言英式英語
關鍵詞Colorectal cancer, Diagnostic marker, Ecology, Microbiota

上次更新時間 2020-28-07 於 04:23