Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells
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AbstractRemote, noninvasive, and reversible control over the nanoscale presentation of bioactive ligands, such as Arg-Gly-Asp (RGD) peptide, is highly desirable for temporally regulating cellular functions in vivo. Herein, we present a novel strategy for physically uncaging RGD using a magnetic field that allows safe and deep tissue penetration. We developed a heterodimeric nanoswitch consisting of a magnetic nanocage (MNC) coupled to an underlying RGD-coated gold nanoparticle (AuNP) via a long flexible linker. Magnetically controlled movement of MNC relative to AuNP allowed reversible uncaging and caging of RGD that modulate physical accessibility of RGD for integrin binding, thereby regulating stem cell adhesion, both in vitro and in vivo. Reversible RGD uncaging by the magnetic nanoswitch allowed temporal regulation of stem cell adhesion, differentiation, and mechanosensing. This physical and reversible RGD uncaging utilizing heterodimeric magnetic nanoswitch is unprecedented and holds promise in the remote control of cellular behaviors in vivo.
All Author(s) ListHeemin Kang, Hee Joon Jung, Dexter Siu Hong Wong, Sung Kyu Kim, Sien Lin, Kai Fung Chan, Li Zhang, Gang Li, Vinayak P. Dravid, Liming Bian
Journal nameJournal of the American Chemical Society
Year2018
Month5
Day9
Volume Number140
Issue Number18
PublisherAmerican Chemical Society
Pages5909 - 5913
ISSN0002-7863
eISSN1520-5126
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry, Multidisciplinary;Chemistry
