Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells
Publication in refereed journal
香港中文大學研究人員
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摘要Remote, noninvasive, and reversible control over the nanoscale presentation of bioactive ligands, such as Arg-Gly-Asp (RGD) peptide, is highly desirable for temporally regulating cellular functions in vivo. Herein, we present a novel strategy for physically uncaging RGD using a magnetic field that allows safe and deep tissue penetration. We developed a heterodimeric nanoswitch consisting of a magnetic nanocage (MNC) coupled to an underlying RGD-coated gold nanoparticle (AuNP) via a long flexible linker. Magnetically controlled movement of MNC relative to AuNP allowed reversible uncaging and caging of RGD that modulate physical accessibility of RGD for integrin binding, thereby regulating stem cell adhesion, both in vitro and in vivo. Reversible RGD uncaging by the magnetic nanoswitch allowed temporal regulation of stem cell adhesion, differentiation, and mechanosensing. This physical and reversible RGD uncaging utilizing heterodimeric magnetic nanoswitch is unprecedented and holds promise in the remote control of cellular behaviors in vivo.
著者Heemin Kang, Hee Joon Jung, Dexter Siu Hong Wong, Sung Kyu Kim, Sien Lin, Kai Fung Chan, Li Zhang, Gang Li, Vinayak P. Dravid, Liming Bian
期刊名稱Journal of the American Chemical Society
出版年份2018
月份5
日期9
卷號140
期次18
出版社American Chemical Society
頁次5909 - 5913
國際標準期刊號0002-7863
電子國際標準期刊號1520-5126
語言英式英語
Web of Science 學科類別Chemistry, Multidisciplinary;Chemistry
