Childhood Cancer Survivorship Work in Asia: A Scoping Review and Directions for Future Research
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The global population of survivors of childhood cancer has grown steadily due to treatment advancements. Unfortunately, cancer survivorship comes at a cost of developing treatment-related complications, and is still an under-researched area in Asia. This scoping review aims to summarize existing literature on clinically-ascertained health outcomes in Asian survivors of childhood cancer treated with contemporary cancer therapies.
A search was conducted on Ovid MEDLINE and EMBASE for studies published after the year 2000; focused on survivors of childhood cancer from countries defined as “Asia” by major cancer organizations; and developed clinical assessments of organ-specific toxicities or/and secondary malignancy at 2 years post-treatment. Studies were excluded if health outcomes were assessed through patient-/proxy- reporting.
Results and discussions
Fifty-six publications fulfilled the inclusion criteria. Studies were conducted on survivors of leukemia (32.1%), CNS tumor (16.0%), and cohorts of survivors with heterogeneous cancer diagnoses (51.9%). The majority of the studies were conducted in developed countries (89.3%) in East and Southeast Asia: Japan (39.2%), South Korea (25.0%), Hong Kong (17.9%), and less in developing countries (10.7%). Most studies were epidemiological in nature and evaluated the prevalence and risk factors for secondary malignancy (8.9%), and complications in one or multiple key organ systems: cardiovascular (23.2%), metabolic/endocrine (obesity, glucose intolerance and growth abnormalities; 25.0%), neurological (brain structural changes, neurocognitive impairment and peripheral neuropathy; 25.0%) infertility (azoospermia and gonadal dysfunction; 8.9%), musculoskeletal (8.9%) and dental (5.4%).
While additional research in childhood cancer treatment in Asia is unquestionably necessary, efforts should also be geared towards survivorship care and research for the emerging population of survivors, especially in Mainland China and other developing countries. Collaborative initiatives can be developed to build a regional repository of systematically-assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors and interventions for late effects in this population.
著者Long Hin Jonathan Poon, Chun-Pong Yu, Chi-Kong Li, Yin Ting Cheung
會議名稱8th Nursing Symposium on Cancer Care
會議地點The Chinese University of Hong Kong

上次更新時間 2018-03-07 於 16:59