Prevalence of Prescription Psychoactive Medication Use in Adolescent Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study (CCSS)
Refereed conference paper presented and published in conference proceedings

香港中文大學研究人員

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其它資訊
摘要Introduction
Long-term survivors of childhood cancer are at-risk for developing physical, emotional, and cognitive late effects which may be managed pharmacologically. The prevalence of psychoactive medication use in adolescent survivors is unknown.

Objectives
To compare the prevalence of psychoactive medication use in adolescent survivors, against adolescent siblings, and identify treatment, clinical and behavioral predictors of medication use.

Methods
Participants included 5665 adolescent (≤18 years old) survivors of childhood cancer from the CCSS and 921 sibling controls (Table 1). Parent-reports of psychoactive medication use and behavioral functioning (Behavior Problems Inventory) were analyzed. Multivariable logistic regression was performed to compare odds ratios (OR) of risk factors for psychoactive medication use, adjusted for age, sex and race.

Results
Survivors were significantly more likely to report psychoactive medication use than non-cancer siblings (18% vs 6%, P<0.001; Table 2). Survivors of CNS tumors or those treated with higher doses of cranial radiation were more likely to use psychoactive medication (Table 3). Cancer-related pain was strongly associated with non-opioid (OR [95%
CI] 5.29 [2.52–11.1]) and opioid (OR 4.83 [2.71–8.63]) analgesic use. Use of stimulants, antidepressants and analgesics was more prevalent in survivors with decreased attention, antisocial behavior and emotional distress (Table 3), as well as those who received special education services (OR 2.39 [2.12–2.70]).

Conclusions
Use of psychoactive medication was more prevalent among adolescent survivors, and was associated with pain and more significant behavior problems. Future research should examine the impact of psychoactive medication use during adolescence on health-related quality of life and functional attainment during adulthood.
出版社接受日期23.04.2018
著者Y.T. Cheung, W. Liu, T.M. Brinkman, D. Srivastava, W.M. Leisenring, R.M. Howell, N.J. Ullrich, K.M. Lommel, P. Brouwers, T.M. Gibson, L.L. Robison, G. Armstrong, K.R. Krull
會議名稱Annual Meeting On Supportive Care in Cancer
會議開始日28.06.2018
會議完結日30.06.2018
會議地點Vienna
會議國家/地區奧地利
會議論文集題名Supportive Care in Cancer
出版年份2018
月份6
卷號26
期次Suppl 2
出版社Springer
頁次S71 - S71
國際標準期刊號0941-4355
電子國際標準期刊號1433-7339
語言美式英語

上次更新時間 2021-18-09 於 01:03