IL-37-mediated anti-inflammatory activity by suppressing the activation of eosinophils in allergic asthma
Refereed conference paper presented and published in conference proceedings


摘要Regulatory IL-37b is a fundamental inhibitor of innate immunity that exerts anti-
inflammatory activity in inflammatory diseases. In this study, IL-37b showed significant
suppression of cytokines and chemokines production in in vitro co-culture of human
eosinophils and bronchial epithelial BEAS-2B cells upon stimulation by bacterial toll-like
receptor-2 (TLR2) ligand peptidoglycan (PGN), while antagonizing the activation of nuclear
factor kappa B (NF-κB), phosphatidylinositol -3-kinase/protein kinase B (PI3K/Akt),
extracellular signal-regulated kinases 1 and 2 (ERK1/2) and suppressing the gene
transcription of PYCARD, S100A9 and CAMP. In ovalbumin (OVA)-induced allergic
asthmatic model, intravenous administration of IL-37b during challenge stage showed higher
potential in ameliorating airway inflammation than treatment during sensitization, as shown
by significantly reduced airway hyper-responsiveness, plasma OVA-specific IgE
concentration, cytokines and chemokines production in plasma, bronchoalveolar lavage fluid
(BALF) and lung homogenate (all p < 0.05). IL-37b also retarded the development of asthma
by suppressing eosinophil count in BALF and up-regulating the percentage of CD25 hi Foxp3 +
regulatory T cells in CD4 + cells in spleen and lung tissues. Similar findings were further
validated by humanized asthmatic NOD/SCID mice model that mimic the human immune
system to confirm the therapeutic potential of IL-37b in allergic asthma.
著者Jing Zhu, Jie Dong, Lu Ji, Peiyong Jiang, Ting Fan Leung, Dehua Liu, Lai Guan Ng, Miranda Sin-Man Tsang, Delong Jiao, Christopher Wai-Kei Lam, Chun-Kwok Wong
會議名稱Hong Kong Society of Flow Cytometry 23rd Annual General Meeting and Scientific Meeting
會議地點Hong Kong

上次更新時間 2018-20-06 於 12:13