Isorhynchophylline Improves Learning and Memory Impairments on TgCRND8 Transgenic Mice
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AbstractAlzheimer’s disease (AD) is the most common form of dementia in elderly people with huge health and economic burden to the society. So far, the treatment for AD is largely unsatisfactory. Isorhynchophylline (IRN) is a c-22 oxindole alkaloid that was isolated from Uncaria. rhynchophylla (Gou-Teng in Chinese). Recent studies in our laboratory have shown that IRN has potent neuroprotective effects in different in vivo and in vitro models of AD. To provide more scientific rationale and justification for future clinical study on this anti-AD alkaloid, the present project aimed to investigate the cognitive deficit ameliorating effects of IRN on TgCRND8 transgenic(Tg) mice.
At the age of four months, the mice were randomly assigned to five groups of 10 animals each: (a) Wild-type + vehicle; (b) Tg + vehicle; (c) and (d) Tg + IRN (20 mg/kg and 40 mg/kg, respectively); (e) Tg + donepezil (5 mg/kg) as positive control. The mice were orally given with IRN, donepezil or vehicle once daily and lasted for 4 months, followed by assessing spatial learning and memory function by the Radial Arm Maze test. The brain tissues were used for mechanistic studies with western blotting method.
The results showed that IRN significantly improved spatial learning and memory function on TgCRND8 transgenic mice. In the mechanistic studies, IRN significantly decreased the phosphorylation of c-Jun and the levels of IDE, PS-1, BACE-1 and APH-1. In the meantime, IRN significantly decreased the level of p-tau(Ser396).
All Author(s) ListLi HQ, Xian YF, Lin ZX
Name of ConferenceInternational Conferences on Alzheimer's and Parkinson Diseases
Start Date of Conference16/04/2018
End Date of Conference18/04/2018
Place of ConferenceTokyo
Country/Region of ConferenceJapan
Year2018
LanguagesEnglish-United Kingdom

Last updated on 2018-25-06 at 15:50