In vitro effects of Huangbo and its single compounds on rheumatoid arthritis using fibroblast like synoviocyte
Refereed conference paper presented and published in conference proceedings

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AbstractRheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial lining of joints, and destruction of cartilages and bones. Patients may suffer from huge pain and develop disability in severe cases. Our previous in vitro, in vivo and clinical studies of Traditional Clinical Formulae containing Huangbo showed inspiring anti-inflammatory and beneficial effects on RA. Therefore, we would like to further investigate the anti-inflammatory activity of Huangbo and its small compounds on RA. In this study, fibroblast like synoviocytes (FLS) from RA patients were stimulated by tumor necrosis factor (TNF)-α after treatment of Huangbo or its small compounds. According to current results, small compound magnoflorine was found to significantly suppress vascular-cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression on FLS, which facilitate the infiltration of immune cells into joints to produce cytokines, leading to sustained inflammation of joints. In addition, magnoflorine was found to significantly suppress secretion of CCL5 and CCL10 from FLS, which are chemoattractant of immune cells. Such results indicated that magnoflorine may have the potential to ameliorate joint inflammation in RA by reducing the infiltration of immune cells into joints. However, magnoflorine also significantly raised the secretion of other chemokines and cytokines, such as IL-6 and IL-8. Therefore, the actual effect of Magnoflorine on RA needs further investigation. The study of the effects of other single compounds is still on going.
All Author(s) ListYau Tsz CHAN, Dehua LIU, Miranda Sin Man TSANG, Jing ZHU, Xiaoyu SUN, Ping Chung LEUNG, Lai Shan TAM, Chun Kwok WONG
Name of ConferenceHong Kong Society of Flow Cytometry 23rd Annual General Meeting and Scientific Meeting
Start Date of Conference03/03/2018
End Date of Conference03/03/2018
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
LanguagesEnglish-United Kingdom

Last updated on 2018-20-06 at 11:58