MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target
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AbstractEndometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with endometriosis and in the peritoneal cavity of a mouse model of surgically induced endometriosis. Majority of MDSCs were granulocytic, produced ROS, and arginase, and suppressed T‐cell proliferation. Depletion of MDSCs by antiGr‐1 antibody dramatically suppressed development of endometrial lesions in mice. The chemokines CXCL1, 2, and 5 were expressed at sites of lesion while MDSCs expressed CXCR‐2. These CXC‐chemokines promoted MDSC migration toward endometriotic implants both in vitro and in vivo. Also, CXCR2‐deficient mice show significantly decreased MDSC induction, endometrial lesions, and angiogenesis. Importantly, adoptive transfer of MDSCs into CXCR2‐KO mice restored endometriotic growth and angiogenesis. Together, this study demonstrates that MDSCs play a role in the pathogenesis of endometriosis and identifies a novel CXC‐chemokine and receptor for the recruitment of MDSCs, thereby providing a potential target for endometriosis treatment.
Acceptance Date14/02/2018
All Author(s) ListZhang Tao, Zhou Juhua, Man Gene Chi Wai, Leung Kam Tong, Liang Bo, Xiao Bo, Ma Xinting, Huang Shaoyan, Huang Huaxiang, Hegde Venkatesh L., Zhong Yin, Li Yanmin, Kong Grace Wing Shan, Yiu Alice Ka Wah, Kwong Joseph, Ng Pak Cheung, Lessey Bruce A., Nagarkatti Prakash S., Nagarkatti Mitzi, Wang Chi Chiu
Journal nameEuropean Journal of Immunology
Year2018
Month6
Volume Number48
Issue Number6
Place of PublicationUSA
Pages1059 - 1073
ISSN0014-2980
LanguagesEnglish-United Kingdom
KeywordsAngiogenesis, CXCR2, Endometriosis, Immunosuppression, Myeloid‐derived suppressor cells

Last updated on 2020-24-09 at 02:34