Convergent synthesis and characterization of fatty acid-conjugated poly(ethylene glycol)-block-poly(epsilon-caprolactone) nanoparticles for improved drug delivery to the brain
Publication in policy or professional journal

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摘要Herein, for the first time, we report the synthesis, preparation, and characterization of fatty acid-conjugated poly(ethylene glycol)-block-poly(epsilon-caprolactone) nanoparticles (FA-NPs), with the ultimate goal of improving drug delivery to the brain. These nanoparticles had a nano-size (<100 nm) with a fairly narrow size distribution (PDI = 0.2–0.3). They were non-hemolytic and non-cytotoxic. By employing curcumin, a poorly soluble herbal molecule, as a model, FA-NPs enhanced the drug solubility by >5.4 × 105x. They showed moderate stability in serum and exhibited zero-order drug release. As a proof-of-concept, the brain uptake of oleic acid-NPs (OA-NPs) was examined in rats after intravenous injections. Relative to 1% DMSO and PEG-NPs formulations, the OA-NPs enhanced the brain accumulation of the loaded cargo by 4.28 and 1.94x, respectively. Apparently, these nanoparticles hold considerable promise in drug delivery to the brain and their potential applications for disorders of the central nervous system should be explored.
著者Ho Yin Li, Bowen Zhang, Pui Shan Chan, Jingwen Weng, Chi Kwan Tsang, Wai Yip Thomas Lee
期刊名稱European Polymer Journal
出版年份2018
月份1
卷號98
頁次394 - 401
國際標準期刊號0014-3057
電子國際標準期刊號1873-1945
語言英式英語

上次更新時間 2020-01-12 於 01:36