Safe use of Chinese medicinal herbs - herb-induced hepatotoxicity
Refereed conference paper presented and published in conference proceedings

香港中文大學研究人員

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摘要The safe use of orthodox drugs and the alternative medicines including Chinese medicinal herbs is always a public concern. Comparing with the orthodox drugs, there are less awareness and investigation on the adverse effects/toxicity induced by herbal preparations. Herbal medicines consist of multiple ingredients acting on multiple targets, which makes the investigation of their adverse effects/toxicity much more difficult and challenging. Among drug-induced toxicities, drug-induced liver injury (DILI) is one of the leading causes of acute liver failure. Unlike well-recognized DILI caused by orthodox drugs, the hepatic impairments caused by natural products, including herbal remedies, often have less public awareness and are also lack of confirmative diagnosis in clinic, although herb-induced liver injury (HILI) has been reported as one of the major causes of DILI worldwide. The diagnosis of HILI is challenging due to the lack of characteristic clinical features and specific biomarkers for the diagnosis. This has subsequently hindered the development of specific and efficacious treatment. Among differential natural products caused HILI, pyrrolizidine alkaloids (PAs) are one of the most significant and responsible phytotoxins. To date, over 660 PAs have been identified in approximately 3% of flowering plants, and about half of PAs have been reported to be hepatotoxic. Yearly, numerous incidences of PA-induced liver injury (PA-ILI) associated with the intake of PA-producing herbal products and/or PA-contaminated foodstuffs have been reported worldwide. In this presentation, using PA-ILI as an example, our methodical translational study, from the identification of clinical problems, to the laboratory basic science for delineating toxic mechanism and developing the mechanism-based specific biomarker, and then the transformation of the biomarker to clinical diagnosis of PA-ILI will be illustrated.
著者Ge LIN
會議名稱2018李时珍中医葯大健康國際高峰論坛
會議開始日25.05.2018
會議完結日28.05.2018
會議地點Hubei
會議國家/地區中國
出版年份2018
月份5
日期25
語言美式英語

上次更新時間 2018-30-11 於 10:44