Interventions for improving colonoscopy screening rate among first-degree relatives of people with colorectal cancer: a systematic review and meta-analysis
Other conference paper


摘要Purpose of the study: To summarize and evaluate the existing evidence of interventions on improving the uptake rate of colonoscopy screening among first degree relatives (FDRs) of people with colorectal cancer (CRC).
Methods: Ten electronic English and Chinese databases were searched, to identify eligible clinical trials from the year 1995 to December 2017.  Studies were selected and appraised independently by two reviewers. The Cochrane risk of bias tool was selected to evaluate the risk of bias among included studies. When possible, data from comparable groups were statistically pooled. Otherwise, a narrative approach was used. 
Results and discussions: Six studies were included, which were grouped as tailored and target intervention. Pooled analysis of tailored intervention studies showed a beneficial effect on motivating colonoscopy in CRC screening context (OR:2.28, 95% CI: 1.73-3.01, P<0.01). Meanwhile, all the tailored interventions were grouped as two subgroups: (1) tailored intervention delivered by print plus telephone; and (2) tailored intervention delivered only by print. The subgroup meta-analysis demonstrated that tailored information sent by telephone plus print had a significant effect on increasing colonoscopy screening uptake (OR:2.56, 95% CI: 1.93-3.40, P<0.01). Besides, the subgroup of tailored intervention delivered only by print involved in the pooled analysis showed a small but non-significant effect on improving colonoscopy use (OR:1.50, 95%CI: 0.66-3.42, P=0.33). The results of meta-analysis indicated tailored intervention delivered by print plus telephone is a promising way to motivate colonoscopy screening. Given the limited number of studies and various methodological flaws (lack of blinding information, measure self-report data without verification and selective reporting) of included studies, more RCT with rigorous study designs are needed. Meanwhile, the evidence for the efficacy of target intervention was not established. 
Conclusions: This review provides preliminary evidence for tailored intervention delivered by print plus telephone is an effective intervention on improving colonoscopy use. Future well-designed RCTs of repeating tailoring intervention are needed to further examine and optimize effect in promoting CRC screening behavior. 
著者BAI Yang, WONG Cho Lee, HE Xiaole, SO Kwok Wei
會議名稱8th Nursing Symposium on Cancer Care
會議地點The Chinese University of Hong Kong

上次更新時間 2019-09-01 於 14:44