Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats
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AbstractA toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.
All Author(s) ListLI Yan-Hong, TAI William Chi-Shing, KHAN Imran, LU Cheng, LU Yao, WONG Wing-Yan, CHAN Wood-Yee, HSIAO Wen-Luan Wendy, LIN Ge
Journal nameJournal of Environmental Science and Health, Part C
Volume Number36
Issue Number2
PublisherTaylor & Francis
Pages65 - 83
LanguagesEnglish-United States
KeywordsAcute hepatotoxicity pyrrolizidine alkaloids, retrorsine, toxicoproteomics

Last updated on 2021-03-03 at 02:22