Anti-proliferative activity of a purified polysaccharide isolated from the basidiomycete fungus Paxillus involutus
Publication in refereed journal

香港中文大學研究人員
替代計量分析
.

其它資訊
摘要A growth-inhibitory polysaccharide (GIPinv) was purified using size-exclusion and ion-exchange chromatography from the fourth sodium hydroxide extraction step of a fungus found in British Columbia. The fungus was genetically identified as a member of the Paxillus involutus complex. GIPinv has an average molecular weight of 229 kDa and is a heteroglycan composed of glucose (65.9%), galactose (20.8%), mannose (7.8%), fucose (3.2%) and xylose (2.3%). GC–MS methylation analysis suggests that GIPinv has mixed linkages in the backbone containing (1 → 6)-Gal (25.5%), (1 → 4)-Glc (18.3%), (1 → 6)-Glc (8.3%), (1 → 3)-Glc (5.3%) and (1 → 2)-Xyl (4.5%). GIPinv has branching points at (1 → 2, 6)-Man (8.6%) and (1 → 3, 6)-Man (4.9%) having unsubstituted fucose (8.3%) and glucose (16.3%) as terminal sugars. GIPinv had growth-inhibitory activity against several cancer cell lines and triggered apoptosis. GIPinv should be further explored as a potential anti-cancer agent and a unique polysaccharide.
出版社接受日期15.11.2017
著者Barad A, Mackedenski S, Li WM, Li XJ, Lim BCC, Rashid F, Tackaberry LE, Massicotte HB, Egger KN, Reimer K, Cheung PCK, Lee CH
期刊名稱Carbohydrate Polymers
出版年份2018
月份2
日期1
卷號181
出版社Elsevier
頁次923 - 930
國際標準期刊號0144-8617
電子國際標準期刊號1879-1344
語言英式英語

上次更新時間 2020-16-09 於 00:41