Myotendinous Properties At The Distal Tibia Assessed By High-Resolution Peripheral Qct And Its Relationship With Age, Lean Mass And Muscle Function
Refereed conference paper presented and published in conference proceedings


摘要Introduction: Sarcopenia, the age-related decline in muscle mass and function, is associated with frailty and increased risk of falls and fracture. High-resolution peripheral quantitative computed tomography (HRpQCT) is an advanced imaging modality in bone microarchitecture quantification at the extremities. Recent development has enabled quantification of myotendinous (muscle and tendon, MT) properties at distal tibia using standard HRpQCT images.
Objectives: To determine the relationship between MT properties at distal tibia assessed by HRpQCT and age, lean mass assessed by whole body dual-energy X-rays absorptiometry (DXA) and muscle function.
Materials and Methods: The present analysis included 266 Chinese men and 431 Chinese women aged 20-90 years, drawn from the Normal Reference Study. All participants completed HRpQCT (XtremeCT I, SCANCO Medical AG, Bruettisellen, Switzerland) assessment at distal tibia using standard in vivo scanning protocol (110 slice at 82μm isotropic voxel size). Images were analyzed using a custom threshold-based algorithm to separate bone, MT, and fat. MT density (MTD) was measured in Hounsfield units (HU). Assessments of appendicular lean mass index (ALMI, kg/m2) and handgrip strength (HGS, kg) assessed by a digital dynamometer were available in 266 men and 267 women.
Results: MTD was 4.7% significantly higher in men than in women and gender-related difference was larger for subjects ≥60 years old (9.5%). However, gender explained only 3.1% variance of MTD. MTD decreased significantly with increasing age and the relationship exhibited a non-linear trend, suggesting faster decrease in older age. A quadratic model with age explained 36.7% and 42.5% variance of MTD in men and women, respectively. After controlling for age, partial correlation showed insignificant relationships between MTD and body weight and height. Lower MTD was significantly associated with lower HGS (r=0.391 in men, 0.409 in women, both p<0.0001). MTD was a significant independent explanatory variable for HGS after adjusted by age, body weight and height. Significant correlation between MTD and ALMI was only found in men (r=0.327, p<0.0001). MTD explained 10.7% variance of ALMI in men and remained a significant independent explanatory variable for ALMI after adjusted by age, and body weight.
Conclusions: HRpQCT-derived MTD at distal tibia is significantly associated with age and muscle function but is less influenced by body size. Significant correlation with ALMI by DXA was only found in men. Future studies are needed to investigate the value of HRpQCT-derived myotendinous properties at distal tibia particularly in the context of ankle joint stabilization and gait function.
著者T. Y. ZHU, V. W. Y. HUNG, C. W. Y. CHOY, C. K. L. CHENG, T. C. Y. KWOK, J. C. Y. CHENG, L. QIN
會議名稱The 4th Asia-Pacific Bone & Mineral Research Meeting and Osteoporotic Fracture Prevention & Treatment Conference 2018
會議地點Hong Kong
會議論文集題名The Proceedings of The 4th Asia-Pacific Bone & Mineral Research Meeting and Osteoporotic Fracture Prevention & Treatment Conference 2018
出版地Hong Kong
頁次44 - 44

上次更新時間 2018-12-06 於 15:19