Unique Correlation Pattern Between Radius Bone Qualities And Handgrip Muscle Strength In Girls With Adolescent Idiopathic Scoliosis
Refereed conference paper presented and published in conference proceedings


摘要Introduction: Previous studies reported adolescent idiopathic scoliosis (AIS) was associated with low bone mass. Handgrip muscle strength was found to be one of the independent predictord of bone mass in normal boys and girls. Cross-talk between bone and muscle might potentially shed lights on the nature of poor bone health and its role in the etiopathogenesis of AIS. To the best of our knowledge, studies on the correlation between bone and muscle parameters in AIS have not been reported in literature.
Objectives: To investigate the correlation between handgrip strength and bone qualities (volumetric bone mineral density (vBMD), bone geometry, trabecular bone micro-architecture) and bone mechanical properties in girls with AIS versus age- matched normal girls.
Materials and Methods: 142 AIS girls and 247 non-AIS girls aged 12-14 years old were recruited. Maximum handgrip strength was measured with a standard dynamometer and bone qualities of non-dominant distal radius were measured by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone mechanical properties were assessed by Finite Element Analysis (FEA). Partial correlation was used to control confounding from age, arm span and weight in data analysis.
Results: After adjustment, handgrip strength in normal girls was positively correlated with bone area (R = 0.17, p = 0.01 in cortical area and R = 0.24, p < 0.001 in trabecular area) and bone mechanical properties (R = 0.25 in stiffness and R = 0.24 in failure load, both p < 0.001), but not correlated with vBMD and trabecular bone micro-architecture. In contrast, handgrip strength in AIS girls was positively correlated with cortical area (R = 0.22, p < 0.01), cortical thickness (R = 0.19, p=0.03), and all bone mechanical properties (R = 0.22 – 0.33, all p < 0.05).
Conclusions: This study indicated unique correlation patterns between bone qualities and handgrip strength in AIS as distinct from controls. This finding suggests the characteristic bone-muscle cross talk in AIS could play an important role in the etiopathogenesis of AIS.
Acknowledgement: This study is supported by RGC of HKSAR (468809, 468411 & 14135016).
著者Cheuk KY, Hung VWY, Yu FWP, Wong LLN, Lee WYW, Cheng JCY, Lam TP
會議名稱The 4th Asia-Pacific Bone & Mineral Research Meeting and Osteoporotic Fracture Prevention & Treatment Conference 2018
會議地點Hong Kong
會議論文集題名The Proceeding of the 4th Asia-Pacific Bone & Mineral Research Meeting and Osteoporotic Fracture Prevention & Treatment Conference 2018
出版地Hong Kong
頁次60 - 60

上次更新時間 2018-12-06 於 14:51