A randomised controlled trial to increase influenza vaccine uptake in children aged from 6 to 24 months
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Influenza vaccine is not included in Hong Kong Government’s universal Childhood Immunisation Programme but children aged from 6 months to 12 years are recommended to receive the vaccine. Subsidised vaccine may be obtained through the Childhood Influenza Vaccination Subsidy Scheme (CIVSS). This study investigated whether a simple intervention package could increase influenza vaccine uptake in Hong Kong children.

Families of children who were enrolled in a previous knowledge, attitudes and practices (KAP) study were invited to participate in this trial when the children reached the age of 6 months. Children who had already received influenza vaccine were excluded. After enrolment, subjects were randomly allocated to control and intervention groups using block randomisation. At recruitment (11 Nov 2014 – 13 Jun 2015), subjects in the control group received the publicly available leaflets from the Centre for Health Protection about the CIVSS. Subjects in the intervention group additionally received the following: (1) a concise information sheet about the risks of influenza to children and importance of vaccination for the prevention of influenza; (2) semi-completed forms necessary to utilise Government subsidy; (3) the contact of clinics in reasonable proximity to subjects’ home that do not charge above the Government subsidy; and (4) text message reminders. The intervention group received the same package at the start of the CIVSS in the following year. At approximately 12 months (3 Aug – 19 Oct 2015) and 24 months (22 Aug – 23 Dec 2016) of age (following the end of an influenza season), children’s influenza vaccination history were obtained. Intention-to-treat analysis was used with missing status of influenza vaccination taken as no vaccination. Chi-square tests were performed to compare influenza vaccine uptakes between control and intervention groups using statistical software R (version 3.4.0).

208 subjects (44% of 493 mother-infant pairs from the previous KAP study) were recruited with 104 subjects in each arm. 33 (32%) and 44 (42%) intervention-children received influenza vaccine by approximately 12 and 24 months of age respectively. 2 (2%) and 7 (7%) control-children received vaccine by the respective age. The intervention significantly increased influenza vaccine uptake in children aged 12 and 24 months (p-value < 0.001) with absolute increases of 30% and 35% respectively.

A simple intervention package of concise information, pre-filled consent forms, practitioner contact details and text message reminders increased influenza vaccine uptake in Hong Kong children from 6 to 24 months of age with an absolute increase of 35%. Implementing this intervention in the community could provide a large potential impact on influenza disease burden.

This work was supported by the Health and Medical Research Fund [Ref.: 14131452].
著者Yeung KHT, Tarrant M, Chan CC, Tam WH, Nelson EAS
會議名稱The Sixth ESWI Influenza Conference
關鍵詞Influenza vaccine, uptake, children, RCT, Hong Kong, influenza, intervention

上次更新時間 2018-04-06 於 10:35