Cerebral Small Vessel Disease Burden Is Associated with Poststroke Depressive Symptoms: A 15-month Prospective Study
Publication in refereed journal


摘要Objective: All types of cerebral small vessel disease (SVD) markers including lacune, white matter hyperintensities (WMH), cerebral microbleeds, and perivascular spaces were found to be associated with poststroke depressive symptoms (PDS). This study explored whether the combination of the four markers constituting an overall SVD burden was associated with PDS.

Methods: A cohort of 563 patients with acute ischemic stroke were followed over a 15-month period after the index stroke. A score of ≥7 on the 15-item Geriatric Depression Scale was defined as clinically significant PDS. Scores of the four SVD markers ascertained on magnetic resonance imaging were summed up to represent total SVD burden. The association between SVD burden and PDS was assessed with generalized estimating equation models.

Results: The study sample had a mean age of 67.0 ± 10.2 years and mild-moderate stroke [National Institutes of Health Stroke Scale score: 3, interquartile, 1–5]. PDS were found in 18.3%, 11.6%, and 12.3% of the sample at 3, 9, and 15 months after stroke, respectively. After adjusting for demographic characteristics, vascular risk factors, social support, stroke severity, physical and cognitive functions, and size and locations of stroke, the SVD burden was associated with an increased risk of PDS [odds ratio = 1.30; 95% confidence interval = 1.07–1.58; p = 0.010]. Other significant predictors of PDS were time of assessment, female sex, smoking, number of acute infarcts, functional independence, and social support.

Conclusion: SVD burden was associated with PDS examined over a 15-month follow-up in patients with mild to moderate acute ischemic stroke.
著者Yan Liang, Yang-kun Chen, Vincent Chung Tong Mok, Defeng Wang, Gabor S. Ungvari, Chiu-wing Winnie Chu, Hee-Ju Kang, Wai Kwong Tang
期刊名稱Frontiers in Aging Neuroscience
關鍵詞cerebral microbleeds, cerebral small vessel disease, depressive symptoms, enlarged perivascular spaces, lacune, poststroke depression, stroke, white matter hyperintensities

上次更新時間 2021-17-09 於 00:04