Trends in serum human chorionic gonadotropin levels 0–4 days after methotrexate administration for predicting tubal ectopic pregnancy treatment success
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Objective:
To evaluate serum human chorionic gonadotropin (HCG) levels 0–4 days after single‐dose methotrexate administration for tubal ectopic pregnancy.
Methods:
The present retrospective study included women with tubal ectopic pregnancy treated by methotrexate at a tertiary hospital in Hong Kong, China, between January 1, 2007, and December 31, 2016. Patients were stratified serum HCG levels rose or fell from day 0–4 post‐administration. Trends in day 0–4 serum HCG to predict treatment success were compared with that of day 4–7 serum HCG. The optimal drop in HCG was identified by receiver operating characteristic curve analysis.
Results:
There were 102 patients included. The positive predictive value (PPV) of day 0–4 serum HCG for treatment success was 91% (95% confidence interval [CI] 82–96), which is comparable to the current criterion of a 15% drop in day 4–7 serum HCG (PPV 91%, 95% CI 84–95). A 6% drop in day 0–4 serum HCG was the best predictor of treatment success (PPV 96%, 95% CI 86–99).
Conclusion:
A drop in day 0–4 serum HCG provided earlier prognostic information and was not inferior to the current criterion.
出版社接受日期05.12.2017
著者Wong Lo, Fung Linda WY, Cheung Chun Wai, Lao Terence T.
期刊名稱International Journal of Gynecology and Obstetrics
出版年份2018
月份5
卷號141
期次2
出版社Wiley
頁次245 - 249
國際標準期刊號0020-7292
電子國際標準期刊號1879-3479
語言英式英語
關鍵詞Human chorionic gonadotrophin, Methotrexate, Tubal ectopic pregnancy

上次更新時間 2021-13-10 於 23:38