The role of interactions of platelets with brain- specific neuronal glycolipids in the modulation of neuronal functions during neurological disorders
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AbstractIn the intact CNS platelets are separated from the neurons and glial cells by the blood-brain barrier (BBB) structure. However, during pathological condition such as the trauma, infection, neurodegeneration, inflammation BBB become compromised leading to direct interaction of neurons with platelets. We have previously found that brain-specific sialated gangliosides within neuronal lipid rafts directly activated platelets. Here we plan to investigate the possible role of platelet-lipid raft interactions in the modulation of neuronal activity in mouse model of epilepsy. We found that the seizure durations were significantly reduced in wild-type (WT) mice with depleted platelets. At the same time, ST3-deficient mice, which lack of brain-specific gangliosides in neuronal lipid rafts, had lower levels of peak seizures with lower mortality rate when compared with WT controls. The activity of neurons was increased when neuronal cells were co-incubated with platelets, both in primarily neural culture and in brain slice organotypic cultures. Thus, we expect to elucidate particular molecular mechanisms how integration of platelets with neuronal lipid rafts modulate neuronal functions and promote seizures.
Acceptance Date14/03/2018
All Author(s) ListKopeikina E., Ponomarev E.D.
Name of Conference18th World Congress of Basic and Clinical Pharmacology (WCP2018)
Start Date of Conference01/07/2018
End Date of Conference06/07/2018
Place of ConferenceKyoto
Country/Region of ConferenceJapan
LanguagesEnglish-United States
Keywordsplatelets, neurons, epilepsy

Last updated on 2018-19-10 at 17:28