A Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy
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AbstractFunctional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐grafted polycaprolactone (DNA‐g‐PCL) brushes to form spherical and nanosized hydrogels via nucleic acid hybridization in which small interfering RNAs (siRNAs) are fully embedded and protected for systemic delivery. Owing to the existence of multivalent mutual crosslinking events inside, the crosslinked nanogels with tunable size exhibit not only good thermostability, but also remarkable physiological stability that can resist the enzymatic degradation. As a novel siRNA delivery system with spherical nucleic acid (SNA) architecture, the crosslinked nanogels can assist the delivery of siRNAs into different cells without any transfection agents and achieve the gene silencing effectively both in vitro and in vivo, through which a significant inhibition of tumor growth is realized in the anticancer treatment.
All Author(s) ListFei Ding, Quanbing Mou, Yuan Ma, Gaifang Pan, Yuanyuan Guo, Gangsheng Tong, Chung Hang Jonathan Choi, Xinyuan Zhu, Chuan Zhang
Journal nameAngewandte Chemie International Edition
Volume Number57
Issue Number12
Pages3064 - 3068
LanguagesEnglish-United States

Last updated on 2020-28-03 at 02:08