Functional investigation of seRNAs in skeletal myogenic differentiation
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摘要Functional specification of cell and tissue types is vital for all metazoans. This requires cells to respond to developmental and environmental cues by generating specific gene expression patterns on the basis of an identical set of genetic materials. Typical enhancers (TEs) are the principal regulatory components of the genome that enable such cell-type and cell-state specificities of gene expression. Recently discovered super enhancers (SEs) describe group of TEs in close genomic proximity with unusually high activity. Findings from fervent efforts in the past two years demonstrate that SEs are key to control the cell identity or lineage during the cell differentiation. More recently with the advanced high throughput analyses enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Emerging evidence suggest that at least some eRNAs contribute to enhancer function and gene activation but their modes of action are largely unknown. To fill the gap, in this study we investigated the mechanistic roles of super-enhancer associated seRNAs using skeletal myoblast differentiation as a model system. Our findings suggest that seRNAs are existent important entities during SE activation by regulating the nearby gene activation through binding to RNA binding proteins; moreover, their induction during myogenic differentiation is orchestrated by key transcription factors such as MyoD.
著者Yu Zhao, Jiajian Zhou, Liangqiang He, Hao Sun, Huating Wang
會議名稱Keystone Symposia: Noncoding RNAs: Form, Function, Physiology
會議開始日25.02.2018
會議完結日01.03.2018
會議地點Keystone, Colorado
會議國家/地區美國
出版年份2018
語言美式英語

上次更新時間 2018-04-05 於 12:53