Functional investigation of seRNAs in skeletal myogenic differentiation
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AbstractFunctional specification of cell and tissue types is vital for all metazoans. This requires cells to respond to developmental and environmental cues by generating specific gene expression patterns on the basis of an identical set of genetic materials. Typical enhancers (TEs) are the principal regulatory components of the genome that enable such cell-type and cell-state specificities of gene expression. Recently discovered super enhancers (SEs) describe group of TEs in close genomic proximity with unusually high activity. Findings from fervent efforts in the past two years demonstrate that SEs are key to control the cell identity or lineage during the cell differentiation. More recently with the advanced high throughput analyses enhancers have been found to be broadly transcribed, resulting in the production of enhancer-derived RNAs, or eRNAs. Emerging evidence suggest that at least some eRNAs contribute to enhancer function and gene activation but their modes of action are largely unknown. To fill the gap, in this study we investigated the mechanistic roles of super-enhancer associated seRNAs using skeletal myoblast differentiation as a model system. Our findings suggest that seRNAs are existent important entities during SE activation by regulating the nearby gene activation through binding to RNA binding proteins; moreover, their induction during myogenic differentiation is orchestrated by key transcription factors such as MyoD.
All Author(s) ListYu Zhao, Jiajian Zhou, Liangqiang He, Hao Sun, Huating Wang
Name of ConferenceKeystone Symposia: Noncoding RNAs: Form, Function, Physiology
Start Date of Conference25/02/2018
End Date of Conference01/03/2018
Place of ConferenceKeystone, Colorado
Country/Region of ConferenceUnited States of America
LanguagesEnglish-United States

Last updated on 2018-04-05 at 12:53