Toward Understanding in Vivo Sequestration of Nanoparticles at the Molecular Level
Publication in refereed journal

香港中文大學研究人員

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摘要A longstanding and widely accepted bottleneck in the targeted delivery of intravenously injected nanoparticles lies in their clearance by macrophages in the liver and spleen. In this Perspective, we call for deeper understanding of the critical role of endothelial cells in the sequestration of nanoparticles in vivo. In this issue of ACS Nano, Campbell et al. used a combination of real-time imaging and genome-editing methods to demonstrate that stabilin-2 is an important receptor for removing anionic liposomes from blood circulation in a zebrafish model. Such mechanistic insights at the molecular level will provide a more holistic picture of the in vivo sequestration of administered nanoparticles beyond the cellular level and pose valuable design considerations for redistributing nanoparticles in vivo.
出版社接受日期21.02.2018
著者YIN Bohan, LI Kin Hei Kelvin, HO Lok Wai Cola, CHAN Cecilia Ka Wing, CHOI Chung Hang Jonathan
期刊名稱ACS Nano
出版年份2018
月份2
日期27
卷號12
期次3
頁次2088 - 2093
國際標準期刊號1936-0851
電子國際標準期刊號1936-086X
語言美式英語

上次更新時間 2020-15-08 於 01:08