The effect of elevated progesterone levels before oocyte retrieval in women undergoing ovarian stimulation for IVF treatment on the genomic profile of peri-implantation endometrium
Publication in refereed journal

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摘要To evaluate the effects of high progesterone prior to oocyte retrieval on the genomic profile of peri-implantation endometrium, we conducted this single-center, prospective cohort study. Depending on whether or not the progesterone level on the day of hCG administration and the day after hCG administration were elevated, a total of 20 women undergoing IVF treatment who did not have fresh embryo transfer were included: Group 1 refers to subjects with normal progesterone level on both days; Group 2 refers to subjects with normal progesterone level on the day of hCG administration and high progesterone level on the day after hCG administration; Group 3 refers to subjects with high progesterone level on the day of hCG administration and normal progesterone level on the day after hCG administration; Group 4 refers to subjects with high progesterone level on both days. Five subjects were included in each group. Endometrial samples were obtained 7 days after hCG administration. We found that high progesterone level prior to oocyte retrieval predominantly affected components of the NK cell mediated cytotoxicity pathway in the endometrium and that significant differences were only seen when progesterone measurements on both the day of and day after hCG administration were considered together.
出版社接受日期12.05.2017
著者Liu L, Huang J, Li TC, Hong XT, Laird S, Dai YD, Tong XM, Zhu HY, Zhang S
期刊名稱Journal of Reproductive Immunology
出版年份2017
月份6
卷號121
頁次17 - 25
國際標準期刊號0165-0378
語言英式英語
關鍵詞Progesterone, Peri-implantation, uNK cell, Endometrium, IVF

上次更新時間 2021-26-04 於 00:09