Zwitterionic-​Salt-​Catalyzed Site-​Selective Monobromination of Arenes
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AbstractA zwitterionic-salt-catalyzed electrophilic monobromination of arenes with high regioselectivity has been developed. Under mild reaction conditions, a wide range of monobrominated aromatic compounds can be obtained in excellent yields. The reaction can be operated using an extremely low catalyst loading (0.05 mol %) with the inexpensive brominating agent N-bromosuccinimide. The versatility of this catalytic protocol has been demonstrated by the scale-up reaction with a 0.01 mol % catalyst loading to provide the selectively halogenated compound in quantitative yield.
Acceptance Date05/08/2017
All Author(s) ListXiong Xiaodong, Tan Fei, Yeung Ying-Yeung
Journal nameOrganic Letters
Volume Number19
Issue Number16
Pages4243 - 4246
LanguagesEnglish-United States

Last updated on 2021-09-01 at 01:17