Platelets are Primary Sensors of Neuronal Damage during Traumatic Brain Injury
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AbstractInflammation in the central nervous system (CNS) is a complex process with a high social and economic impact worldwide. Currently there is no effective therapy for prevention and treatment of CNS inflammation that accompany many neurodegenerative diseases such as multiple sclerosis (MS) or Alzheimer’s disease. In this talk I will give an example of regulation of inflammation in the CNS by platelets. Platelets respond to а vascular damage, but their role in the neurodegenerative diseases is not well known. We found that administration of brain lipid rafts induced a massive platelet activation and degranulation resulting in anaphylaxis in mice. Platelets reacted with sialated gangliosides integrated in lipid rafts of astrocytes and neurons. The brain-specific gangliosides GT1b and GQ1b were recognized by the platelets and this recognition occurred during disruption of blood brain barrier. During neuroinflammation, platelets accumulated in the CNS and secreted proinflammatory factors such as IL-1 and serotonin (5-HT). Further implications of pathogenic and regulatory roles of platelets and their direct interactions with autoimmune CD4 T cells in MS will be further discussed. Thus the study determines a new role of platelets as “innate immune cells” that directly recognize a neuronal damage and contribute to inflammation in the CNS.
All Author(s) ListVeremeyko T., Dukhinova M., Yung A., Ponomarev E.D.
Name of ConferenceVIIth International Congress on Stress Response in Biology and Medicine
Start Date of Conference15/09/2015
End Date of Conference19/09/2015
Place of ConferenceHuangshan City
Country/Region of ConferenceChina
Year2015
LanguagesEnglish-United States
Keywordsplatelets, glycolipids, brain injury, gangliosides

Last updated on 2018-22-06 at 14:46