Asymmetric Total Syntheses of Colchicine, beta-Lumicolchicine, and Allocolchicinoid N-Acetylcolchinol-O-methyl Ether (NCME)
Publication in refereed journal

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其它資訊
摘要A concise and highly enantioselective synthesis of colchicine (>99% ee) in eight steps and 9.3% overall yield, without the need for protecting groups, was developed. A unique Wacker oxidation was used for enabling regioselective construction of the highly oxidised and synthetic challenging tropolone C-ring. Furthermore, asymmetric syntheses of beta-lumicolchicine and N-acetylcolchinol-O-methyl ether (NCME) were achieved. Notably, NCME was synthesised from beta-lumicolchicine by an unusual decarboxylation and electrocyclic ring-opening cascade reaction.
出版社接受日期20.07.2017
著者Xin Liu, Ya-Jian Hu, Bo Chen, Long Min, Xiao-Shui Peng, Jing Zhao, Shaoping Li, Henry N. C. Wong, Chuang-Chuang Li
期刊名稱Organic Letters
出版年份2017
月份9
日期1
卷號19
期次17
出版社American Chemical Society
出版地Columbus, Ohio
頁次4612 - 4615
國際標準期刊號1523-7060
電子國際標準期刊號1523-7052
語言美式英語
關鍵詞Colchicine, beta-Lumicolchicine, N-Acetylcolchinol-O-methyl Ether (NCME), Total Synthesis

上次更新時間 2020-21-10 於 01:19