Asymmetric Darzens Reaction of Isatins with Diazoacetamides Catalyzed by Chiral BINOL–Titanium Complex
Publication in refereed journal

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摘要An efficient catalytic asymmetric Darzens reaction of N-protected isatins with diazoacetamides using a chiral BINOL/Ti(OiPr)4 complex as the catalyst has been developed. This reaction is a straightforward method for the synthesis of spiro-epoxyoxindoles in 40–95% yields, up to >20:1 dr and up to >99% ee. A gram-scale reaction was also achieved in 95% yield with excellent stereoselectivity and enantioselectivity (>20:1 dr, >99% ee).
出版社接受日期26.09.2017
著者Guo-Li Chai, Jian-Wei Han, Henry N. C. Wong
期刊名稱Journal of Organic Chemistry
出版年份2017
月份12
日期1
卷號82
期次23
出版社American Chemical Society
出版地Columbus, Ohio
頁次12647 - 12654
國際標準期刊號0022-3263
語言美式英語
關鍵詞Asymmetric Darzens reaction, Isatins, BINOL, Tetraphenylenes.

上次更新時間 2020-21-10 於 01:19