Roles of Selective Oxysterol-binding Protein Related Proteins in Autophagosome formation in Arabidopsis
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AbstractAutophagosome is a double membrane bounded organelle for cytoplasmic compartments degradation and recycling. During autophagosome formation, several kinds of phospholipid were identified to be crucial for autophagosome initiation, maturation and fusion with lysosome/vacuole. Previous studies have shown that phosphatidylinositol 4-phosphate (PI4P) is essential for the formation of normal sized autophagosomes and autophagosome-lysosome fusion. Oxysterol-binding protein (OSBP) related proteins (ORPs) constitute a family of sterol and phospholipids binding and transfer proteins in eukaryotes. Recent studies have shown that ORPs can bind and counter-transfer PI4P and other lipids at membrane contact sites (MCSs) in mammalian cells and yeast. In plant, conserved ORPs are identified but their functions remain unknown. Here, we identified specific ORPs that are localized on the autophagosome membrane by subcellular localization study. These selected ORPs were demonstrated to be involved in autophagy pathway in plants by interaction experiment and autophagy induction studies. Further studies will investigate their possible roles in autophagosome formation in plant. We hypothesize that these plant ORPs may regulate autophagosome membrane PI4P homeostasis and autophagosome formation. Supported by grant from the Research Grants Council of Hong Kong (CUHK14130716, CUHK2/CRF/11G, C4011-14R, C4012-16E and AoE/M-05/12).
All Author(s) ListHao YE, Liwen JIANG
Name of ConferenceCold Spring Harbor Asia conference on Plant Cell and Development Biology
Start Date of Conference22/05/2017
End Date of Conference26/05/2017
Place of ConferenceSuzhou
Country/Region of ConferenceChina
LanguagesEnglish-United States

Last updated on 2018-16-04 at 18:24