Case-control study for disease phenotypes associated with respiratory rhinovirus infection in Hong Kong children
Refereed conference paper presented and published in conference proceedings

摘要Background and Aims: Human rhinovirus (HRV) is the major pathogen for a range of acute respiratory infections and wheezing illnesses in children. Among the genogroups A, B and C, HRV-A and HRV-C were more prevalent and clinically important than HRV-B. Our published results suggested that HRV-C was associated with childhood asthma exacerbation. However, the clinical manifestations and associations with asthma and different lower respiratory tract infection for different HRV species remain unclear. This study aimed to investigate the epidemiology and disease spectrum of HRV detected in Hong Kong children between 2014 autumn to 2015 spring.

Methods: This retrospective study obtained archived nasopharyngeal aspirate (NPA) samples from patients aged below 18 years who were hospitalized for acute respiratory illnesses in a university-affiliated hospital during the periods September-November 2014 and January-April 2015. Their clinical information was retrieved from computerised record. HRV was detected by RT-PCR, and isolates were sequenced to determine the genogroups and serotypes.

Results: 90 patients whose NPA was positive for HRV and 160 patients being negative for an extended panel of respiratory viruses by multiplex PCR method were identified. Mean age of these groups was 3.6 years and 3.5 years respectively. HRV infection was significantly associated with asthma exacerbation (OR 16.54, 95% CI 7.11-38.48), wheezing illnesses (OR 8.90, 95% CI 4.74-16.71) and lower respiratory tract infection (OR 3.53, 95% CI 2.15-5.78). Among patients with HRV and asthma exacerbations, HRV-C was more commonly found than HRV-A (75% vs 25%; OR 2.50, 95% CI 0.66-9.47). Similar proportions of HRV-A and HRV-C were found in patients with upper respiratory tract infection. We observed a trend towards changes in HRV from HRV-C in 2014 autumn to HRV-A in 2015 spring (HRV-A: 20.9% vs 34.0%). The predominant HRV serotypes in these two periods changed from HRV-C-8713-MY-10 to HRV-A30/HRV-C15.

Conclusions: HRV is a strong risk factor for asthma exacerbations and wheezing illnesses in Hong Kong children. Although these disease associations were mainly accounted for by HRV-C, the predominant HRV species isolated from our hospitalised children changed from HRV-C in 2014 autumn to HRV-A in 2015 spring. Prospective studies with larger sample size are needed to confirm our observations.
著者Ting-Fan Leung, Agnes Sze-Yin Leung, Yu-Ping Song, Kin-Pong Tao, Haichao Wang, Man-Fung Tang, Gary
Wing-Kin Wong, Renee Wan-Yi Chan
會議名稱13th Congress of Asian Society for Pediatric Research
會議地點Hong Kong
會議論文集題名13th Congress of Asian Society for Pediatric Research

上次更新時間 2018-11-05 於 14:43